N-acetylcysteine Attenuates Cigarette Smoke-induced Alveolar Epithelial Cell Apoptosis through Reactive Oxygen Species Depletion and Glutathione Replenish In vivo and In vitro

CONCLUSION: Our study confirmed that NAC can attenuate CS-induced AEC apoptosis via alleviating ROS-mediated ER stress and mitochondrial dysfunction pathway, and the mechanism was found to be related to replenishing the cellular GSH content.PMID:37921125 | DOI:10.2174/0113892010257526231019143524

Source: Current Pharmaceutical Biotechnology - November 3, 2023 Category: Biotechnology Authors: Jie Zhao Mi Han Yange Tian Peng Zhao Xuefang Liu Haoran Dong Suxiang Feng Jiansheng Li Source Type: research