Predictive IDH Genotyping Based on the Evaluation of Spatial Metabolic Heterogeneity by Compartmental Uptake Characteristics in Preoperative Glioma Using 18F-FET PET

Conclusion: We proposed parametric 18F-FET PET as a noninvasive metabolic biomarker for the evaluation of CU characteristics, which differentiated IDH genotype with excellent diagnostic performance, establishing a critical association between spatial metabolic heterogeneity, mitochondrial tricarboxylic acid cycle, and genomic features with critical implications for clinical management and the diagnostic workup of patients with central nervous system cancer.

Source: Journal of Nuclear Medicine - November 2, 2023 Category: Nuclear Medicine Authors: Lohmeier, J., Radbruch, H., Brenner, W., Hamm, B., Tietze, A., Makowski, M. R. Tags: Clinical Investigations Source Type: research