Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism

AbstractHigher coffee consumption has been associated with reduced dementia risk, yet with inconsistencies across studies. CYP1A2 polymorphisms, which affects caffeine metabolism, may modulate the association between coffee and the risk of dementia and Alzheimer ’s disease (AD). We included 5964 participants of the Three-City Study (mean age 74 years-old), free of dementia at baseline when they reported their daily coffee consumption, with available genome-wide genotyping and followed for dementia over a median of 9.0 (range 0.8–18.7) years. In Cox prop ortional-hazards models, the relationship between coffee consumption and dementia risk was modified by CYP1A2 polymorphism at rs762551 (p for interaction = 0.034). In multivariable-adjusted models, coffee intake was linearly associated with a decreased risk of dementia among carriers of the C al lele only (“slower caffeine metabolizers”; HR for 1-cup increased [95% CI] 0.90 [0.83–0.97]), while in non-carriers (“faster caffeine metabolizers”), there was no significant association but a J-shaped trend toward a decrease in dementia risk up to 3 cups/day and increased risk beyond. T hus, compared to null intake, drinking ≥ 4 cups of coffee daily was associated with a reduced dementia risk in slower but not faster metabolizers (HR [95% CI] for ≥ 4 vs. 0 cup/day = 0.45 [0.25–0.80] and 1.32 [0.89–1.96], respectively). Results were similar when studying AD and ano ther CYP1A2 candidate polymorphis...
Source: European Journal of Epidemiology - Category: Epidemiology Source Type: research