Regulatory T Cell Inhibition by P60 Combined with Adenoviral AFP Transduced Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma

CONCLUSION: In this study, we showed that vaccination with alpha-fetoprotein-expressing dendritic cells in combination with a specific inhibition of regulatory T-cells by using P60 leads to synergistic tumor inhibition and prolonged survival. This emphasizes the importance of regulatory T-cells inhibition for obtaining an effective antitumoral immune response in hepatocellular carcinoma.PMID:37846958 | DOI:10.1080/08820139.2023.2261980

Source: Immunological Investigations - October 17, 2023 Category: Allergy & Immunology Authors: Farsaneh Sadeghlar Julia Seelemann Annabelle Vogt Christian M öhring Taotao Zhou Robert Mahn Miroslaw Kornek Veronika Lukacs-Kornek Noelia Casares Juan Jos é Lasarte Pablo Sarobe Cornelius van Beekum Hanno Matthaei Steffen Manekeller J örg Kalff Ingo G Source Type: research