4. Comprehensive next generation cytogenomics improves risk stratification of acute myeloid leukemia
Cytogenetic diagnostics including karyotyping, FISH, and chromosome microarray are regularly applied in cases of suspected leukemia, including acute myeloid leukemia (AML). Each of these three tests can identify non-overlapping sets of chromosome aberrations known to have prognostic or diagnostic value. Because each test addresses different classes of prognostic variants, all three tests are often performed in series or in parallel, adding time and expense to the diagnostic process. Here we describe OncoTerra, a platform based on proximity ligation sequencing (PLS), that can be used to identify variants commonly assayed by karyotyping, FISH, and array in a single assay.
Source: Cancer Genetics and Cytogenetics - Category: Genetics & Stem Cells Authors: Stephen Eacker, Alexander Muratov, Maika Malig, Brad Nelson, Mary Wood, Michael VanDyke, Kyle Langford, Lan Beppu, Olga Sala-Torra, Cecilia Yeung, Shawn Sullivan, Ivan Liachko, Jerald Radich Source Type: research
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