Impact of Folinic Acid Dosing on Efficacy and Toxicity of High-Dose Methotrexate in Central Nervous System Lymphoma

High-dose methotrexate (HDMTX)-based regimens are the treatment of choice in primary central nervous system lymphoma (PCNSL). Folinic acid (FA) rescue is used to mitigate the toxic effects of MTX on normal cells. However, the optimal dosing of FA in PCNSL remains uncertain.

Source: Clinical Lymphoma, Myeloma and Leukemia - October 31, 2023 Category: Hematology Authors: Arnon Haran, Noa Gross Even-Zohar, Michal Haran, Eyal Lebel, Shlomzion Aumann, Adir Shaulov, Moshe Gatt, Boaz Nachmias Tags: Original Study Source Type: research