Safety, Tolerability, and Pharmacokinetics of Same-Knee Intra-Articular Injection of Corticosteroid and Lorecivivint Within 7 Days: An Open-Label, Randomized, Parallel-Arm Study

ConclusionNo safety signals were observed. There were no quantifiable plasma concentrations of LOR in either Treatment Sequence. The PK of TCA was unaffected by previous LOR injection. These results suggest that IA administration of LOR and TCA in close time proximity is unlikely to pose a safety concern.Trial RegistrationClinicalTrials.gov identifier, NCT04598542.

http://link.springer.com/10.1007/s40744-023-00604-7

Source: Rheumatology and Therapy - October 30, 2023 Category: Rheumatology Source Type: research