AC Immune highlights a-syn PET study

In this study, Hansson and colleagues performed F-18 ACI-12589 PET imaging in 23 participants with a-synuclein related disorders, 11 with other neurodegenerative disorders, and eight controls. The analysis revealed that F-18 ACI-12589 demonstrated clear binding in the cerebellar white matter and middle cerebellar peduncles of MSA patients, regions known to be highly affected by a-synuclein pathology.(a) Transversal images at the level of the middle cerebellar peduncles in a control participant, and patients with dementia with Lewy bodies (DLB), multiple system atrophy-cerebellar subtype (MSA-C), and Parkinson’s disease (PD). (b) Transversal images at the level of the basal ganglia in a control participant, and patients with DLB, MSA-parkinsonian type. SUVR images for (a, b) have been created using the occipital cortex as a reference region. Image courtesy of Nature Communications.“Our results indicate that a-synuclein pathology in MSA can be identified using F-18 ACI-12589 PET imaging, potentially improving the diagnostic work-up of MSA,” the researchers wrote.The results represent a major step for AC Immune in its further goal to develop precision medicine for neurodegenerative diseases, the company added.The full article is available here.
Source: AuntMinnie.com Headlines - Category: Radiology Authors: Tags: Industry News Source Type: news