Mammalian cysteine ‐rich secretory proteins interact with plasma membrane Ca2+ exporter PMCA4b

ConclusionOur study identifies PMCA4b as a target of multiple mammalian CRISPs and unravels a new role of CRISPs in regulating calcium homeostasis. Differences in the interaction of different CRISPs with cholesterol may regulate their enrichment in the lipid rafts and redistribution in the membrane post-capacitation, thereby affecting their interaction with PMCA4b.

Source: Andrology - October 26, 2023 Category: Urology & Nephrology Authors: Vaidehi Miya, Chandan Kumar, Ananya A. Breed, Susan Idicula ‐Thomas, Bhakti R. Pathak Tags: ORIGINAL ARTICLE Source Type: research