Metabolic regulation in erythroid differentiation by systemic ketogenesis in fasted mice

Red blood cells (RBCs) formation from progenitor cells in bone marrow (BM) requires enormous energy supply through a stepwise metabolic switch from oxidative phosphorylation to glycolysis during erythropoiesis 1,2. Glucose and glutamine act as the principal nutrient source for nucleotide biosynthesis to regulate the commitment of human and murine hematopoietic stem cells (HSCs) to the erythroid lineage 3. It was reported that control of erythroid differentiation and maturation is also fine-tuned by fatty acids and cholesterol through the regulation of metabolic shift 4,5.

Source: Experimental Hematology - October 25, 2023 Category: Hematology Authors: Wenjuan Ma, Yuichiro Arima, Terumasa Umemoto, Tomomasa Yokomizo, Yuqing Xu, Kenichi Miharada, Yosuke Tanaka, Toshio Suda Tags: Article Source Type: research