m-Cresol,a pesticide intermediate, induces hepatotoxicity and behavioral abnormalities in zebrafish larvae through oxidative stress, apoptosis

In this study, zebrafish larvae were used to comprehensively study the hepatotoxicity of m-cresol and explore its molecular mechanism. After 72 hpf of fertilization, zebrafish larvae were exposed to 0.2 mM,0.4 mM, and 0.6 mM of m-Cresol. Varying degrees of liver injury and behavioral abnormalities were observed. The hepatotoxicity of zebrafish larvae may be induced by oxidative stress pathway and apoptosis of cell.PMID:37871866 | DOI:10.1016/j.tiv.2023.105723

Source: Toxicology in Vitro - October 23, 2023 Category: Toxicology Authors: Ying Wang Jie Wu Mengqi Wan Dou Yang Fasheng Liu Kehao Li Manxin Hu Yuanyuan Tang Huiqiang Lu Shouhua Zhang Yuanzhen Xiong Source Type: research