Cavin ‐2 promotes fibroblast‐to‐myofibroblast trans‐differentiation and aggravates cardiac fibrosis

ConclusionsCavin-2 loss suppressed fibroblast trans-differentiation into myofibroblasts through the TGF- β/Smad signalling. The loss of Cavin-2 in cardiac fibroblasts suppresses cardiac fibrosis and may maintain cardiac function.

Source: ESC Heart Failure - October 24, 2023 Category: Cardiology Authors: Yusuke Higuchi, Takehiro Ogata, Naohiko Nakanishi, Masahiro Nishi, Yumika Tsuji, Shinya Tomita, Simon J. Conway, Satoaki Matoba Tags: Original Article Source Type: research