Large method differences for free thyroid hormone assays in the hyperthyroid range can affect assessment of hyperthyroid status: Comparison of Abbott Alinity to Roche Cobas, Siemens Centaur and equilibrium dialysis LC-MS/MS

CONCLUSION: Measured free thyroid hormone concentrations are highly method-dependent, especially at high FT4 concentrations. Clinicians treating hyperthyroid patients should be aware that patients appear much less hyperthyroid from FT4-measurements performed using Alinity compared to Cobas or Centaur. Guideline-recommended antithyroid drug dosages based on FT4 (including multiples of the upper reference range) have to be adjusted to the FT4 method used. FT4 results from different methods should be clearly distinguished (e.g. separate lines) in medical records.PMID:37848158 | DOI:10.1016/j.clinbiochem.2023.110676

Source: Clinical Biochemistry - October 17, 2023 Category: Biochemistry Authors: Alexander Bauer Westbye Finn Erik Aas Sandra R Dahl Svetlana N Zykova Oskar Kelp Louise K Dahll Per M Thorsby Source Type: research