Glimepiride, a novel soluble epoxide hydrolase inhibitor, protects against heart failure via increasing epoxyeicosatrienoic acids

Epoxyeicosatrienoic acids (EETs), which exert multiple endogenous protective effects, are hydrolyzed into less active dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase (sEH). However, commercial drugs related to EETs or sEH are not yet in clinical use.

Source: Journal of Molecular and Cellular Cardiology - October 21, 2023 Category: Cytology Authors: Chengcheng Zhao, Xiangrui Jiang, Liyuan Peng, Yan Zhang, Huihui Li, Qiumeng Zhang, Yinhui Wang, Feipu Yang, Junfang Wu, Zheng Wen, Zuowen He, Jingshan Shen, Chen Chen, Dao Wen Wang Source Type: research