Pathophysiology of sarcopenia: Genetic factors and their interplay with environmental factors
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass and function. This disorder has been associated with a range of adverse health outcomes, including fractures, functional deterioration, and increased mortality. The pathophysiology of sarcopenia is highly complex and multifactorial, involving both genetic and environmental factors as key contributors. This review consolidates current knowledge on the genetic factors influencing the pathogenesis of sarcopenia, particularly focusing on the altered gene expression of structural and metabolic proteins, growth factors, hormones, and inflammatory cytokines.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Arif Muhammad Aslam, Eun Bi Ma, Joo Young Huh Source Type: research
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