Heart rate lowering for coronary CTA with Ivabradine in atrial fibrillation

Atrial fibrillation (AF) poses a challenge for adequate heart rate (HR) lowering prior to coronary computed tomography angiography (CCTA). Ivabradine inhibits If channels expressed in the sinoatrial node and is commonly used for HR lowering prior to CCTA in patients presenting in a sinus rhythm.1 If channels were initially believed to be solely expressed in the sinoatrial node until the discovery of hyperpolarization-activated cyclic nucleotide-gated cation channel 4 (HCN4), the primary gene responsible for If current expression, throughout the myocardium including the atrioventricular node (AVN).
Source: Journal of Cardiovascular Computed Tomography - Category: Radiology Authors: Tags: Correspondence Source Type: research