Overcoming muscle stem cell aging

Curr Opin Genet Dev. 2023 Oct 13;83:102127. doi: 10.1016/j.gde.2023.102127. Online ahead of print.ABSTRACTReduced muscle strength and mass is one of the hallmarks of physiological aging in humans and can result in severe impairment of the quality of life. In part this is caused by a functional loss of the highly specialized muscle stem cells (MuSCs), which in healthy conditions provide maintenance, growth, and regeneration. Recent progress in understanding of the stem cell niche and results from single cell technologies reveal exciting insights at unprecedented detail into MuSCs and muscle biology during aging. Here, we review this field and discuss the implications of current findings with a focus on cellular reprogramming approaches as a novel therapeutic avenue for age-related muscle decline.PMID:37839315 | DOI:10.1016/j.gde.2023.102127
Source: Current Opinion in Genetics and Development - Category: Genetics & Stem Cells Authors: Source Type: research