Novel aloe emodin –hydroxyethyl piperazine hybrid dihydrochloride induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways

This study provides new insights into the further development of anthraquinone compounds as potential chemotherapeutic agents for oral cancer treatment.The novel aloe emodin derivativeAE-NPC induces oral cancer CAL-27 cells apoptosis through ROS production, DNA damage and mitochondrial pathways. The anthraquinone compoundAE-NPC may be a potential agent for the treatment of oral cancer.

http://link.springer.com/10.1007/s00044-023-03157-0

Source: Medicinal Chemistry Research - October 19, 2023 Category: Chemistry Source Type: research