Neurotensin--regulated miR-133{alpha} is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis

Conclusions
NT-associated colitis and inflammatory signalling are regulated by miR-133α-AFTPH interactions. Targeting of miR-133α or AFTPH may represent a novel therapeutic approach in inflammatory bowel disease.

Source: Gut - June 9, 2015 Category: Gastroenterology Authors: Law, I. K. M., Bakirtzi, K., Polytarchou, C., Oikonomopoulos, A., Hommes, D., Iliopoulos, D., Pothoulakis, C. Tags: Ulcerative colitis, Open access, Gastrointestinal hormones Inflammatory bowel disease Source Type: research