Adjunctive agents to antipsychotics in schizophrenia: a systematic umbrella review and recommendations for amino acids, hormonal therapies and anti-inflammatory drugs

Conclusions The results of this umbrella review should be interpreted with caution as the number of RCTs included in the meta-analyses was generally small and the effect sizes were weak or medium. For NAC, two RCTs with low risk of bias have provided conflicting results and the WFSBP-grade recommendation included also the results of meta-analyses. These drugs could be provisionally prescribed for patients for whom no other treatments have been effective, but they should be discontinued if they prove ineffective.

http://mentalhealth.bmj.com/cgi/content/short/26/1/e300771?rss=1

Source: Evidence-Based Mental Health - October 18, 2023 Category: Psychiatry & Psychology Authors: Fond, G., Mallet, J., Urbach, M., Benros, M. E., Berk, M., Billeci, M., Boyer, L., Correll, C. U., Fornaro, M., Kulkarni, J., Leboyer, M., Llorca, P.-M., Misdrahi, D., Rey, R., Schürhoff, F., Solmi, M., Sommer, I. E. C., Stahl, S. M., Pignon, B., Tags: Open access Adult mental health Source Type: research