Pharmacodynamics and Pharmacokinetics of Fluticasone Furoate/Vilanterol in Healthy Chinese Subjects

ConclusionIn healthy Chinese subjects, minimal and non–clinically relevant β‐adrenergic pharmacodynamic effects were observed with FF/VI doses ranging from 50/25 to 200/25 μg. FF dose‐dependent reductions in serum cortisol levels of 15–25% were seen after administration of FF/VI 100/25 and 200/25 μg. FF/VI was safe and well tolerated in these subjects at doses ranging from 50/25 to 200/25 μg.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fphar.1598

Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - May 1, 2015 Category: Drugs & Pharmacology Authors: Xia Chen, Xin Zheng, Ji Jiang, Pei Hu, Kai Wu, Lihong Zhuang, Lian Liu, Xin Du, Rodger Kempsford, Ann Allen Tags: Original Research Article Source Type: research