Generation and validation of a myoglobin knockout zebrafish model

In conclusion, we have generated three mb knockout lines with indistinguishable phenotypes during embryonic and larval development and validated one of these lines, mb(Auzf13.2), to have no signs of genetic compensation or off-target effects in the adult heart. These findings suggests that the mb(Auzf13.2) shows promise as a candidate for investigating the biological role of Mb in zebrafish.PMID:37847464 | DOI:10.1007/s11248-023-00369-3

Source: Transgenic Research - October 17, 2023 Category: Genetics & Stem Cells Authors: Rasmus Hejlesen Kasper Kj ær-Sørensen Angela Fago Claus Oxvig Source Type: research