Protective effect of olopatadine hydrochloride against LPS-induced acute lung injury: via targeting NF- κB signaling pathway

ConclusionIn nutshell, inhibition of NF- κB pathway by Olo resulted in protection and reduced mortality in LPS- induced ALI and thus has potential to be used clinically to arrest disease progression in ALI/ARDS, since the drug is already in the market. However, the findings warrant further extensive studies, and also future studies can be planned to elucidate its role in COVID-19-associated ARDS or cytokine storm.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research