Linking Neurogenetics and Functional Connectivity in Autism

The large neurobiological heterogeneity of autism spectrum disorder (ASD) and its genetic diversity have challenged our ability to identify how genetic risk translates into changes of brain structure and function and, finally, into behavioral symptoms. Various lines of evidence, stemming from genetics (1,2), neuroimaging [reviewed in (3)], and behavioral phenotyping (4), have highlighted the subtle and multifactorial mechanisms underlying the disease, which have resulted in limited success developing novel therapeutics.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research