Factors affecting overall survival and disease-free survival after surgery for hepatocellular carcinoma: a nomogram-based prognostic model —a Western European multicenter study

This study aimed to evaluate the prognostic factors in HCC patients for OS and DFS outcomes and establish a nomogram-based prognostic model to predict the DFS of HCC. A multicenter, retrospective European study was conducted through the collection of data on 413 consecutive treated patients with a first diagnosis of HCC between January 2010 and December 2020. Univariate and multivariate Cox regression analyses were performed to identify all independent risk factors for OS and DFS outcomes. A nomogram prognostic staging model was subsequently established for DFS and its precision was verified internally by the concordance index (C-Index) and externally by calibration curves. For OS, multivariate Cox regression analysis indicated Child –Pugh B7 score (HR 4.29; 95% CI 1.74–10.55;p = 0.002) as an independent prognostic factor, along with Barcelona Clinic Liver Cancer (BCLC) stage ≥ B (HR 1.95; 95% CI 1.07–3.54;p = 0.029), microvascular invasion (MVI) (HR 2.54; 95% CI 1.38–4.67;p = 0.003), R1/R2 resection margin (HR 1.57; 95% CI 0.85–2.90;p = 0.015), and Clavien–Dindo Grade 3 or more (HR 2.73; 95% CI 1.44–5.18;p = 0.002). For DFS, multivariate Cox regression analysis indicated BCLC stage ≥ B (HR 2.15; 95% CI 1.34–3.44;p = 0.002) as an independent prognostic factor, along with multiple nodules (HR 2.04; 95% CI 1.25–3.32;p = 0.004), MVI (HR 1.81; 95% CI 1.19–2.75;p = 0.005), satellite nodules (HR 1.63; 95% CI 1.09–2.4...
Source: Updates in Surgery - Category: Surgery Source Type: research