Development of an isogenic human cell trio that models polyglutamine disease

This study thus demonstrates the potential of UKiS, which is a beneficial platform for the efficient development of cell models not only for polyQ diseases but also for any other genetic diseases, which may accelerate our deeper understanding of disease mechanisms and cell-based screening for therapeutic drugs.PMID:37821389 | DOI:10.1266/ggs.22-00030

Source: Genes and Genetic Systems - October 11, 2023 Category: Genetics & Stem Cells Authors: Tomoyuki Ohno Takeshi Nakane Taichi Akase Hikaru Kurasawa Yasunori Aizawa Source Type: research