Immune-related neurodegeneration in the midbrain causes pulmonary dysfunction in murine cryptococcal IRIS

Trends Neurosci. 2023 Oct 6:S0166-2236(23)00223-0. doi: 10.1016/j.tins.2023.09.005. Online ahead of print.ABSTRACTCryptococcal immune reconstitution inflammatory syndrome (C-IRIS) is a condition that affects immunosuppressed individuals recruited to antiretroviral therapy. In a recent publication, Kawano and colleagues used a mouse model to demonstrate that pulmonary dysfunction, one of the fatal complications of C-IRIS, is caused by T cell-driven neurodegeneration in a vital medullary nucleus of the brain responsible for respiratory control.PMID:37806831 | DOI:10.1016/j.tins.2023.09.005
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research