Towards correlative archaeology of the human mind

Biol Chem. 2023 Oct 12. doi: 10.1515/hsz-2023-0199. Online ahead of print.ABSTRACTRetracing human cognitive origins started out at the systems level with the top-down interpretation of archaeological records spanning from man-made artifacts to endocasts of ancient skulls. With emerging evolutionary genetics and organoid technologies, it is now possible to deconstruct evolutionary processes on a molecular/cellular level from the bottom-up by functionally testing archaic alleles in experimental models. The current challenge is to complement these approaches with novel strategies that allow a holistic reconstruction of evolutionary patterns across human cognitive domains. We argue that computational neuroarcheology can provide such a critical mesoscale framework at the brain network-level, linking molecular/cellular (bottom-up) to systems (top-down) level data for the correlative archeology of the human mind.PMID:37819768 | DOI:10.1515/hsz-2023-0199
Source: Biological Chemistry - Category: Chemistry Authors: Source Type: research