Effect of tapered versus stable treatment with tumour necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial

Conclusion In patients with RA in remission for more than 1 year while using TNFi, an increase in flare rate was reported in those who tapered TNFi to discontinuation. However, most regained remission after reinstatement of full-dose treatment. Trial registration numbers EudraCT: 2012-005275-14 and clinicaltrials.gov: NCT01881308.

http://ard.bmj.com/cgi/content/short/82/11/1394?rss=1

Source: Annals of the Rheumatic Diseases - October 12, 2023 Category: Rheumatology Authors: Lillegraven, S., Paulshus Sundlisaeter, N., Aga, A.-B., Sexton, J., Olsen, I. C., Lexberg, A. S., Madland, T. M., Fremstad, H., Hoili, C. A., Bakland, G., Spada, C., Haukeland, H., Hansen, I. M., Moholt, E., Uhlig, T., Solomon, D. H., van der Heijde, D., Tags: Open access, ARD Lay summaries, ARD, Rheumatoid arthritis Source Type: research