Combination treatment of persistent COVID-19 in immunocompromised patients with remdesivir, nirmaltrevir/ritonavir and tixegavimab/cilgavimab

We present a retrospective study on the treatment outcomes of severely immunocompromised patients with persistent COVID-19. The study analyzed data from 14 patients who received a combination of tixegavimab/cilgavimab and antiviral medications. Response was evaluated based on symptom improvement, PCR cycle-threshold values, and C-reactive protein levels. Eleven patients achieved complete clinical and virological resolution, while three showed partial responses. The study suggests a potential association between non-response and tixegavimab/cilgavimab neutralization. The findings underscore the need for tailored treatment approaches and further research on optimal strategies for managing persistent COVID-19, as well as the development of antivirals and variant-specific monoclonal antibodies.PMID:37805361 | DOI:10.1016/j.jmii.2023.09.004

Source: Journal of Microbiology, Immunology, and Infection - October 7, 2023 Category: Microbiology Authors: Tal Brosh-Nissimov Nir Ma'aravi Daniel Leshin-Carmel Yonatan Edel Sharon Ben Barouch Yafit Segman Amos Cahan Erez Barenboim Source Type: research