L ‐F001, a multifunctional fasudil–lipoic acid dimer, antagonizes hypoxic–ischemic brain damage by inhibiting the TLR4/MyD88 signaling pathway

ConclusionsL-F001 antagonizes the inflammatory response after hypoxic-ischemia by inhibiting the activation of the TLR4 signaling pathway, thus playing a neuroprotective role. L-F001 may be a potential therapeutic agent for neonatal HIBD.

Source: Brain and Behavior - October 12, 2023 Category: Neurology Authors: Ruiyu Zhou, Liqiang Wu, Ni Jin, Sha Sha, Ying Ouyang Tags: ORIGINAL ARTICLE Source Type: research