Survival Outcomes of Limited-Stage Diffuse Large B-cell Lymphoma Treated with Radiation Therapy

Patients with favorable risk limited-stage (LS) diffuse large b-cell lymphoma (DLBCL) have shown excellent outcomes without radiotherapy (RT). However, the role of RT for the remainder of LS-DLBCL patients is less well defined. We aimed to investigate whether the addition of RT provided an overall survival (OS) benefit in a real-world cohort of LS-DLBCL patients based on primary site at presentation. Retrospective data from 39,745 patients with stage I and II DLBCL treated with front-line combination chemotherapy alone or followed by RT were identified using the National Cancer Database from 2004 to 2015.

Source: Clinical Lymphoma, Myeloma and Leukemia - October 9, 2023 Category: Hematology Authors: Daniel A. Ermann, Victoria A. Vardell, Harsh Shah, Lindsey Fitzgerald, Randa Tao, David K. Gaffney, Deborah M. Stephens, Boyu Hu Source Type: research