Oral digoxin effects on Lac- regulation during intense intermittent exercise using small and large contracting muscle mass in healthy humans

Introduction: Introduction: The cardiac glycoside, digoxin, is a specific Na+,K+-ATPase (NKA) inhibitor used to treat patients with severe heart failure and atrial fibrillation. Digoxin inhibits myocardial NKA causing increased cardiac contractility, but also specifically binds to, and inhibits a fraction of NKA in skeletal muscle. Skeletal muscle NKA preferentially utilises ATP derived from glycogenolytic and glycolytic origins, therefore the aim of this study was to determine whether digoxin effects on muscle NKA would reduce systemic lactate [Lac-] with intense exercise and exacerbate fatigue in healthy humans.

Source: Journal of Science and Medicine in Sport - October 1, 2023 Category: Sports Medicine Authors: S. Sostaric, A. Petersen, C. Goodman, X. Gong, T. Aw, M. Brown, A. Garnham, C. Steward, K. Murphy, K. Carey, J. Leppik, S. Fraser, D. Cameron-Smith, H. Krum, R. Snow, M. McKenna Tags: O2023SMA-284 Source Type: research