Abnormal network connections to early visual cortex in posterior cortical atrophy

Posterior Cortical Atrophy (PCA), a visual variant of Alzheimer's disease, initially manifests with higher-order visual disorders and parieto/temporo-occipital atrophy. Recent studies have shown remote functional impairment in both distant brain networks and along the calcarine sulcus (V1). Functional alteration in the calcarine differs along its length, reflecting center to periphery visual space differences. Herein, we aim to connect between these two sets of findings by looking at the retinotopic patterns of functional connectivity between large-scale brain networks and V1, comparing patients with normally sighted subjects.

Source: Journal of the Neurological Sciences - October 5, 2023 Category: Neurology Authors: Atira Bick, Ayelet McKyton, Glick-Shames Haya, Netaniel Rein, Netta Levin Source Type: research