Physiological and regenerative functions of sterile- α motif protein-14 in hematopoiesis

Samd14 promotes signal pathway duration and intensity in hematopoietic stem/progenitor cells (HSPCs) and erythroid progenitors downstream of stem cell factor (SCF) and erythropoietin (Epo) stimulation during regenerative erythropoiesis [1,2]. Samd14 shares homology with neurabin proteins (PPP1R9A and PPP1R9B), which promote cell signaling and survival in neurons [3]. Neurabin mechanisms of action include signaling complex recruitment to actin filaments and controlling specificity of signaling pathway activation within certain cell subtypes [4,5].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research