Prescription Opioid Misuse, Pain Interference, Resilience, and Anxiety Among Chinese People Living with HIV: A Moderated Mediation Model

This study examined POM and its underlying psychological mechanism using data of PLWH with pain (n = 116) from a cohort study in Guangxi. The PROCESS macro was employed to examine a hypothesized moderated mediation model among pain interference, resilience, anxiety, and POM. Results showed 10.3% PLWH engaged in past-three-month POM. After controlling for demographics, HIV-related clinical ou tcomes, and pain severity, anxiety mediated the association between pain interference and POM (β = 0.46,95% CI  = 0.01 to 10.49), and the mediation was moderated by resilience (moderated mediation index  = − 0.02,95% CI  = − 0.784 to − 0.001). Chinese PLWH seem to misuse opioids to cope with pain-related anxiety. Resilience appears to offer protection.
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research