P151 Serum adipokines in Duchenne muscular dystrophy: relationships to BMI, corticosteroids, and muscle fat fraction

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder hallmarked by muscle degeneration, replacement by fat, and weakness. Corticosteroids slow disease progression, but they also cause metabolic disruptions such as significant weight gain. For this preliminary study, we evaluated levels of serum adipokines, or factors released by adipose tissue, in a large cohort of individuals with DMD. 309 serum samples were collected from 94 participants with DMD (longitudinal samples) and 14 controls (one time point) enrolled in the ImagingDMD natural history study.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research