P325 A comparative single nuclei transcriptomics approach to evaluating the terminally differentiated lymphocytes in autoimmune myositis

The utilization of genome-based studies has allowed the expansion of our understanding to encompass the role of transcriptomics in providing a more comprehensive picture of the diseases. However, the existing studies appear to be limited by the relative paucity of categorizing the gene signatures in relation to the spectrum of the cell types from which the signatures emerge from under the specific disease categories. Particularly for the inflammatory cells, single nuclei (sNuc) transcriptomics (RNA-seq) can characterize the gene expression in terminally differentiated lymphocytes and predict the myogenic and non-myogenic cells that interact with it to show the role of these lymphocytes in the immunopathologic mechanism behind the disease.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research