Role of Onabotulinum Toxin-A Injection in the Management of Pain and Sexual Dysfunction in Women with BPS/IC

AbstractPurpose of ReviewIn this review, we aimed to summarize the effects of BoNT-A injections on pain and sexual dysfunction in women with BPS/IC in the light of current literature.Recent FindingsIn recent years, randomized controlled studies have provided evidence for the positive effects of intravesical BoNT-A treatment on pain and quality of life scores in patients with BPS/IC. Trigonal injections have demonstrated similar efficacy and safety to those administered to the bladder body. Furthermore, noninvasive alternatives such as low-energy shock wave plus intravesical instillation, hydrogel-based instillation, and liposome-encapsulated BoNT-A instillations have been explored for patients with BPS/IC. The studies examining the impact of BoNT-A on sexual functions are limited. Only one published study has shown improvement in sexual functions with intravesical BoNT-A.SummaryIntravesical BoNT-A treatment in BPS/IC patients is an effective and safe method recommended by the guidelines. In the light of current literature, this treatment also provides an improvement in sexual functions.
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research