Phenoage and longitudinal changes on transthoracic echocardiography in Alstr öm syndrome: a disease of accelerated ageing?

The objective is to explore whether AS is a disease of accelerated ageing and whether changes over time on echoc ardiography could reflect accelerated cardiac ageing. Cross-sectional measurement of Phenoage and retrospective analysis of serial echocardiography were performed between March 2012 and November 2022. The setting is a single national tertiary service jointly run by health service and patient charity . Forty-five adult patients aged over 16 years were included, 64% were male and 67% of White ethnicity. The median Phenoage was 48 years (interquartile range [IQR]: 35–72) in the 34 patients for whom this was calculable, which was significantly higher than the median chronological age of 29 years (IQR: 22–39,p<0.001). Phenoage was higher than chronological age in 85% (N=29) of patients, with a median difference of +18 years (IQR: +4, +34). On echocardiography, significant decreases were observed over time in left ventricular (LV) size at end-diastole (average of 0.046 cm per year,p<0.001) and end-systole (1.1% per year,p=0.025), with significant increase in posterior wall thickness at end-diastole (0.009 cm per year,p=0.008). LV systolic function measured by global longitudinal strain reduced (0.34 percentage points per year,p=0.020) and E/e ’lat increased (2.5% per year,p=0.019). Most AS patients display a higher Phenoage compared to chronological age. Cardiac changes in AS patients were also reflective of accelerated ageing, with a reduction in LV size and...
Source: AGE - Category: Geriatrics Source Type: research