Pharmacokinetics of Levetiracetam Seizure Prophylaxis in Severe Traumatic Brain Injury

CONCLUSION AND RELEVANCE: Neurocritically ill patients exhibit rapid levetiracetam clearance resulting in a short elimination half-life. Findings of this study suggest regimens of levetiracetam 500 mg every 6 hours, 1000 mg every 8 hours, or 2000 mg every 12 hours may be required for optimal therapeutic target attainment. Patient weight of 75 kg may serve as a breakpoint for weight-guided dosing to optimize levetiracetam therapeutic target attainment for seizure prophylaxis.PMID:37776163 | DOI:10.1177/10600280231202246

Source: The Annals of Pharmacotherapy - September 30, 2023 Category: Drugs & Pharmacology Authors: Sarah Schuman Harlan Carolyn D Philpott Shaun P Keegan Molly E Droege Aniruddha S Karve Brandon Foreman Devin Wakefield Eric W Mueller Kiranpal Sangha Laura B Ngwenya Joshua D Courter Pankaj Desai Christopher Droege Source Type: research