Association Study of Esomeprazole Pharmacokinetics and CYP2C19 Gene Polymorphisms

AbstractTo investigate the association between esomeprazole pharmacokinetics andCYP2C19 gene polymorphisms in a cohort of 95 healthy Chinese participants. A cohort of 95 participants was assembled and stratified into 2 distinct groups, receiving either 20 or 40  mg of esomeprazole through oral administration. The subjects encompassed 17 poor metabolizers, 47 intermediate metabolizers, and 31 rapid metabolizers, and their genotypes were ascertained using the polymerase chain reaction–restriction fragment length polymorphism technique. Esomeprazole plasma concentrations were quantified employing a high-performance liquid chromatography–ultraviolet method. Pharmacokinetic parameters were computed via Phoenix WinNonlin 6.1 software, while SPSS 26.0 facilitated statistical analysis to contrast the pharmacokinetics and theCYP2C19 genotypes. In the aftermath of administering 20 or 40  mg esomeprazole, marked differences were discerned between terminal elimination half-life, maximum concentration/dose, and area under the plasma concentration–time curve from time zero to infinity/dose of esomeprazole (P <  .05), with the exception of time to maximum concentration. The findings of this investigation signify a significant association between esomeprazole metabolism andCYP2C19 gene polymorphisms. There were no unprecedented adverse events documented subsequent to the administration of 20 and 40  mg esomeprazole dosages. Esomeprazole has manifested promising safety and toler...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research