In silico protein dynamics in the human cytoplasm: partial folding, misfolding, fold switching, and non ‐native interactions

This study demonstrates that even fast-folding proteins can get stuck in non-native states in the cell, making them useful models for protein-chaperone interactions and early stages of aggregate formation relevant to cellular disease.This article is protected by copyright. All rights reserved.

Source: Protein Science - September 30, 2023 Category: Biochemistry Authors: Premila P. Samuel Russell, Meredith M. Rickard, Mayank Boob, Martin Gruebele, Taras V. Pogorelov Tags: RESEARCH ARTICLE Source Type: research