Kidney Function as a Key Driver of the Pharmacokinetic Response to High ‐Dose L‐Carnitine in Septic Shock

ConclusionsHigh-dose L-carnitine supplementation is well-described by a two-compartment population PK model in patients with septic shock. Kidney function estimates that leverage cystatin C provided superior model fit. Future investigations into high-dose L-carnitine supplementation should consider baseline metabolic status and dose adjustments based on renal function over a fixed or weight-based dosing paradigm.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: RESEARCH ARTICLE Source Type: research