SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells
Conclusions/interpretationTaken together, these data highlight an important link between ER Ca2+ homeostasis and proinsulin processing in beta cells. Our findings suggest a model whereby chronic ER Ca2+ depletion due to SERCA2 deficiency impairs the spatial regulation of prohormone trafficking, processing and maturation within the secretory pathway.Data availabilityRNA-seq data have been deposited in the Gene Expression Omnibus (GEO; accession no.: GSE207498).Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research
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