Exploring virulence in Mycobacterium bovis: clues from comparative genomics and perspectives for the future

AbstractHere we provide a summary of a plenary lecture delivered onMycobacterium bovis, the bovine TB bacillus, at theM. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences betweenM. bovis and the human pathogenMycobacterium tuberculosis as a route to gain knowledge on what makesM. bovis function as an animal pathogen. We provide a brief historical background aroundM. bovis and comparative virulence experiments withM. tuberculosis, before moving to what we have learned from the studies of theM. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence inM. bovis into improved control of bovine tuberculosis.
Source: Irish Veterinary Journal - Category: Veterinary Research Source Type: research