Course-, dose-, and stage-dependent toxic effects of prenatal acetaminophen exposure on fetal long bone development

In conclusion, PAcE caused development toxicity and multi-cellular function inhibition in fetal long bone, particularly in the high dose, multiple treatments and mid-pregnancy group, and the alteration of canonical Wnt signalling pathway may be its potential mechanism.PMID:37741353 | DOI:10.1016/j.toxlet.2023.09.007

Source: Toxicology Letters - September 23, 2023 Category: Toxicology Authors: Chi Ma Xufeng Li Hao Xiao Bin Li Hanwen Gu Yu Guo Hui Wang Yinxian Wen Liaobin Chen Source Type: research