Early chest CT abnormalities to predict the subsequent occurrence of chronic lung allograft dysfunction

ConclusionsCTi and CTf in the monitoring of LTx patients could predict CLAD. Moderate pulmonary artery stenosis, mosaic pattern, parenchyma condensations, and pleural effusions were risk factors for CLAD.Critical relevance statementThere is a potential predictive role of chest CT in the follow-up of LTx patients for chronic lung allograft dysfunction (CLAD). Early chest CT should focus on pulmonary artery stenosis (risk factor for CLAD in this study). During the follow-up (at least 9 months post-LTx), parenchymal consolidations and pleural effusions were shown to be risk factors for CLAD, and death in subgroup analyses.Key points• Pulmonary artery stenosis (30–50%) on initial chest-CT following lung transplantation predicts CLAD HR = 4.5; CI [1.6–13.2].• Pleural effusion and consolidations 1 year after lung transplantation predict CLAD and death.• Early evaluation of lung transplanted patients should evaluate pulmonary artery anastomosis.Graphical Abstract
Source: Insights into Imaging - Category: Radiology Source Type: research