Orthodontic Management of Severe Hypodontia and Impacted Maxillary Second Molars in a Patient with Sotos Syndrome

Cleft Palate Craniofac J. 2023 Sep 21:10556656231201834. doi: 10.1177/10556656231201834. Online ahead of print.ABSTRACTSotos syndrome is a genetic disorder characterized by distinct craniofacial features, overgrowth in childhood, and impaired intellectual development. We herein report the successful orthodontic treatment of a 14-year-old boy with Sotos syndrome caused by a heterozygous mutation in the NSD1 gene. He showed severe hypodontia, impaction of the maxillary second molars and a skeletal Class III jaw-base relationship. Orthodontic management, including space control by protraction of the maxillary first molars and traction of the impacted molars, was performed using fixed appliances and miniscrews. As a result, acceptable occlusion was obtained without any discernible relapse 18 months postretention.PMID:37735913 | DOI:10.1177/10556656231201834
Source: The Cleft Palate-Craniofacial Journal - Category: ENT & OMF Authors: Source Type: research