Discovery of new Schistosoma mansoni aspartyl protease inhibitors by structure-based virtual screening

CONCLUSION: Overall, the inhibitors identified in this work represent promising hits for further hit-to-lead optimisation.PMID:37672425 | PMC:PMC10481938 | DOI:10.1590/0074-02760230031

Source: Memorias do Instituto Oswaldo Cruz - September 6, 2023 Category: Infectious Diseases Authors: B árbara Figueira Gomes Mario Roberto Senger Jos é Teófilo Moreira-Filho Fabio Jorge de Vasconcellos Junior Rafael Ferreira Dantas Raymond Owens Carolina Horta Andrade Bruno Junior Neves Floriano Paes Silva-Junior Source Type: research